fluoxetine and diclofenac interaction on food intake in goldfish, carassius auratus

نویسندگان

mohammad navid forsatkar faculty of natural resources, department of fisheries, university of tehran, karaj, iran.

maryam hedayatirad faculty of natural resources, department of fisheries, university of tehran, karaj, iran.

kazem kookaram faculty of natural resources, department of fisheries, university of tehran, karaj, iran.

mohammad ali nematollahi faculty of natural resources, department of fisheries, university of tehran, karaj, iran.

چکیده

this study was carried out to investigate the interaction of simultaneous use of fluoxetine (flx), a selective serotonin reuptake inhibitor, and diclofenac (dcf), a nonsteroidal anti-inflammatory drug, on food intake in goldfish, carassius auratus . treatments with different dosage of flx including control, 0, 1, and 10  µg/g body weight (bw) were injected in the fish with mean weight of 30.16 ± 8.57 g every other day in total of 5 times. then fish were exposed to 3 different levels of dcf including 0, 10, and 100 mg/l for 5 days. injection of fluoxetine significantly decreased food intake and consequently body weight. after 5 days exposure to dcf, the amount of food intake in the dcf receiving treatments of 1 mg/l and 10 mg/l was significantly larger than that of 0 mg/l dcf recieving treatment in both the flx dosage groups of 1 μg/g bw and 10 μg/g bw. our results indicated that dcf inhibits behavioral change effects of flx showing the complex effects of pharmaceuticals on fish.

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عنوان ژورنال:
international journal of aquatic biology

جلد ۲، شماره ۴، صفحات ۱۷۲-۰

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